Xogot Skill
Debug Godot games on iPhone/iPad via USB:
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Debug Godot games on iPhone/iPad via USB:
Comprehensive analytics tool for forecasting breakthrough therapeutic technologies by integrating multi-dimensional data sources including clinical development pipelines, intellectual property landscapes, and capital mar.
Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and ...
Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), MSIngs, MANTIS, MSIPanel, MSIDetect, and ngsMSI for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pair...
Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved laye...
Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response...
End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.
Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:0...
Entlassmanagement nach § 39 Abs. 1a SGB V: Rahmenvertrag Entlassmanagement, Patienteneinwilligung, Verordnungsbefugnis (AU, Heil-/Hilfsmittel, AM), Schnittstelle ambulante Versorgung im Krankenhausrecht.
Strategie mit medizinischen Gutachten im SG-Verfahren. Wie laeuft Gutachten Welche Fragen welcher Arzt. Vorbereitung Untersuchung und Reaktion auf Gutachten.
Gutachten Atteste Bescheinigungen: prüft die einschlägigen Voraussetzungen, Dokumente, Risiken und Ausnahmen. Norm-/Quellenanker: GOÄ §§ 1-14 und Anlage, BGB Behandlungsvertrag §§ 630a ff., PKV/Beihilfe-Regelungen, Berufsrecht, aktuelle GOÄ-Reformhinweise im Goae Gebührenordnung Aerzte.
FDA MedTech Compliance Auditor workflow skill. Use this skill when the user needs Expert AI auditor for Medical Device (SaMD) compliance, IEC 62304, and 21 CFR Part 820. Reviews DHFs, technical files, and software validation and the operator should preserve the upstream workflow, copied support f...
Analyzes expert witness reports, depositions, and testimony to identify gaps in medical record review, map conflicts to the full record set, and produce impeachment and admissibility analysis with pinpoint citations. Use when reviewing expert reports for missing medical records, selective review ...
Drafts an IRB-ready Informed Consent Form (ICF) for FDA-regulated clinical trials compliant with 21 CFR 50.25, 50.27, and ICH-GCP. Use when drafting or revising consent documents for Phase I–IV trials, IND studies, or other FDA-regulated protocols requiring IRB submission.
Drafts regulatory-compliant informed consent forms for healthcare procedures, clinical trials, research participation, or professional services. Incorporates HIPAA, FDA, IRB/Common Rule, and ICH-GCP requirements as applicable. Use when drafting surgical consent, research participant agreements, c...
Creates verified, Bates-cited chronological summaries of medical records for litigation. Extracts treatment timelines, providers, diagnoses, procedures, medications, and causation evidence with every clinical fact traceable to a specific Bates range. Identifies gaps, inconsistencies, pre-existing...
Drafts Investigator Agreements for FDA-regulated clinical trials between sponsors and principal investigators. Covers 21 CFR Parts 50, 56, 312/812, ICH GCP E6(R2), IRB governance, data integrity, IP, indemnification, financial terms, and termination. Use when preparing clinical trial investigator...
Structures test validation with precision, accuracy, linearity, and reference range establishment. Use when validating new assays, documenting method comparisons, or establishing reference ranges.
Creates structured operative notes with findings, technique, specimens, and estimated blood loss. Use when dictating operative reports, documenting surgical procedures, or recording intraoperative findings.
Drafts FDA Investigational New Drug (IND) applications under 21 CFR Part 312, including Form 1571, Investigator's Brochure, clinical protocols, CMC sections, and nonclinical data packages. Use when preparing IND submissions, pre-IND packages, IND amendments, or clinical trial authorization docume...
Produces structured medical malpractice case summaries from medical records for personal injury litigation. Extracts chronological care narratives, identifies potential standard-of-care breaches, traces causation, assesses damages, and flags expert needs and statute of limitations issues. Use whe...
Monitors and documents hospital-acquired infections, pressure injuries, and other preventable conditions. Use when tracking HACs, documenting nosocomial events, or reporting patient safety indicators.
Produces a litigation-ready analysis of medical bills and supporting records for personal injury, medical-malpractice, workers'-compensation, and disability cases. Validates CPT/HCPCS/ICD-10 codes against documentation, applies a per-charge causation screen, runs a UCR/FAIR Health/MPFS reasonable...
Applies ESI triage methodology to assign acuity levels based on presenting complaints, vital signs, and resource needs. Use when triaging ED patients, assigning acuity scores, or prioritizing emergency cases.
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