🦖 Equity Scorer
Compute HEIM diversity and equity metrics from VCF or ancestry data. Generates heterozygosity, FST, PCA plots,
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Compute HEIM diversity and equity metrics from VCF or ancestry data. Generates heterozygosity, FST, PCA plots,
Query GTEx (Genotype-Tissue Expression) portal for tissue-specific gene expression, eQTLs (expression quantitative trait loci), and sQTLs. Essential for linking GWAS variants to gene regulation, understanding tissue-specific expression, and interpreting non-coding variant effects.
Federated variant lookup across 9 genomic databases — GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ),
Fetch a region of cis-eQTL summary statistics from EBI eQTL Catalogue v7+ via tabix-on-FTP. Use when an agent needs eQTL beta / SE / p-value for every variant in a window around a gene's TSS for one specific dataset (study × tissue × quantification method). Input: dataset_id, chromosome, start, e...
Wrapper skill for running nf-core/rnaseq bulk RNA-seq preprocessing from FASTQ or BAM inputs with strict preflight, reproducibility outputs, and downstream handoff to ClawBio bulk RNA-seq DE skills.
Wrapper skill for running nf-core/scrnaseq upstream single-cell RNA-seq preprocessing from FASTQ with strict preflight, reproducibility outputs, and downstream handoff to ClawBio scRNA skills.
Differential expression analysis for label-free quantitative (LFQ) intensity data with standard MaxQuant and
Use when you need to connect to the SciGraph SCP server for CISREG (genomic regulation knowledge graph about enhancers, TADs, genes, proteins, phenotypes) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration ...
Use when you need to connect to the SciGraph SCP server for Healx (rare disease drug repositioning biomedical knowledge graph by Healx Ltd.) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration with SCP-HUB-A...
Use when you need to connect to the SciGraph SCP server for InstructProteinKG (UniProt/Swiss-Prot derived protein knowledge graph for sequence-text alignment and instruction learning) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including ...
Use when you need to connect to the SciGraph SCP server for KG-MTL (knowledge graph enhanced multi-task learning framework for molecular interaction prediction: DTI/CPI) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp...
Use when you need to connect to the SciGraph SCP server for PPIKG (BioGRID+UniProt protein–protein interaction knowledge graph for target deconvolution) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration wi...
AI-powered spatial integration of multi-omics datasets using probabilistic alignment for comprehensive tissue atlas construction and cellular state mapping.
Use when you need to connect to the SciGraph SCP server for TransFOL (multimodal biomedical knowledge graph for drug-drug interaction prediction and complex relational/logical reasoning) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), includi...
Use when you need to connect to the SciGraph SCP server for TxGNN (large-scale biomedical knowledge graph for drug repurposing and therapeutic relationship prediction, Neo4j-imported) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including ...
Summarise pre-computed differential expression results with ranked gene lists, biological themes, and publication-ready
Automated sequencing quality control and advanced visualization wrapping FastQC, MultiQC, and custom chart generation. Exposes an MCP stdio server for live AI integration alongside a ClawBio CLI runner.
Analyze a single FASTA file (nucleotide or protein), compute sequence-level metrics (GC, ORFs, MW, pI, GRAVY, secondary-structure fractions) with Biopython, and write a Markdown report plus structured JSON for downstream chaining.
Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis
Use when building a sample-level hierarchical clustering dendrogram from a bulk expression matrix and sample annotation table, especially for QC, batch inspection, or sample similarity assessment. Trigger keywords: hierarchical clustering, dendrogram, sample QC, batch inspection, sample similarit...
Use Bio.PDB to parse and analyze protein structures (PDB/mmCIF) for structural bioinformatics tasks; use when you need structure parsing, geometry calculations, or structural comparison/superposition.
Query the ChEMBL database for bioactive molecules, targets, bioactivities, and approved drugs; use this when you need to filter by physicochemical properties (e.g., MW, LogP), chemical structure (SMILES), or retrieve drug mechanism information.
Compute organ-specific biological age from Olink proteomic data using Goeminne et al. (2025) elastic net aging
End-to-end GWAS automation wrapping PLINK2 for genotype QC and REGENIE for two-step whole-genome regression association
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