🥚 Proteomics Differential Expression
Differential expression analysis for label-free quantitative (LFQ) intensity data with standard MaxQuant and
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Differential expression analysis for label-free quantitative (LFQ) intensity data with standard MaxQuant and
Use when you need to connect to the SciGraph SCP server for CISREG (genomic regulation knowledge graph about enhancers, TADs, genes, proteins, phenotypes) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration ...
Use when you need to connect to the SciGraph SCP server for Healx (rare disease drug repositioning biomedical knowledge graph by Healx Ltd.) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration with SCP-HUB-A...
Use when you need to connect to the SciGraph SCP server for InstructProteinKG (UniProt/Swiss-Prot derived protein knowledge graph for sequence-text alignment and instruction learning) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including ...
Use when you need to connect to the SciGraph SCP server for KG-MTL (knowledge graph enhanced multi-task learning framework for molecular interaction prediction: DTI/CPI) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp...
Use when you need to connect to the SciGraph SCP server for PPIKG (BioGRID+UniProt protein–protein interaction knowledge graph for target deconvolution) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including streamableHttp configuration wi...
AI-powered spatial integration of multi-omics datasets using probabilistic alignment for comprehensive tissue atlas construction and cellular state mapping.
Use when you need to connect to the SciGraph SCP server for TransFOL (multimodal biomedical knowledge graph for drug-drug interaction prediction and complex relational/logical reasoning) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), includi...
Use when you need to connect to the SciGraph SCP server for TxGNN (large-scale biomedical knowledge graph for drug repurposing and therapeutic relationship prediction, Neo4j-imported) and call its MCP tools (query_cypher, get_kg_statistics, get_entity_details, get_experiment_workflow), including ...
Summarise pre-computed differential expression results with ranked gene lists, biological themes, and publication-ready
Automated sequencing quality control and advanced visualization wrapping FastQC, MultiQC, and custom chart generation. Exposes an MCP stdio server for live AI integration alongside a ClawBio CLI runner.
Analyze a single FASTA file (nucleotide or protein), compute sequence-level metrics (GC, ORFs, MW, pI, GRAVY, secondary-structure fractions) with Biopython, and write a Markdown report plus structured JSON for downstream chaining.
Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis
Use when building a sample-level hierarchical clustering dendrogram from a bulk expression matrix and sample annotation table, especially for QC, batch inspection, or sample similarity assessment. Trigger keywords: hierarchical clustering, dendrogram, sample QC, batch inspection, sample similarit...
Use Bio.PDB to parse and analyze protein structures (PDB/mmCIF) for structural bioinformatics tasks; use when you need structure parsing, geometry calculations, or structural comparison/superposition.
Query the ChEMBL database for bioactive molecules, targets, bioactivities, and approved drugs; use this when you need to filter by physicochemical properties (e.g., MW, LogP), chemical structure (SMILES), or retrieve drug mechanism information.
Compute organ-specific biological age from Olink proteomic data using Goeminne et al. (2025) elastic net aging
End-to-end GWAS automation wrapping PLINK2 for genotype QC and REGENIE for two-step whole-genome regression association
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
Deterministic multi-sample QC triage for identity, sex, contamination, and batch-shift outliers
Run pathway and gene-set enrichment analysis on gene lists or ranked gene data, then interpret the results. Use whenever the user has a set of genes (differentially expressed genes from PyDESeq2/Scanpy, CRISPR-screen hits, cluster marker genes, proteomics hits) and wants to know which biological ...
End-to-end bulk RNA-seq orchestrator — takes raw FASTQ reads through QC and trimming (FastQC, fastp/Trim Galore), alignment and quantification (STAR, Salmon, featureCounts), assembles a gene-level counts matrix, then hands off to differential expression (pydeseq2), pathway/GSEA enrichment (pathwa...
Fetch a regional slice of plasma pQTL summary statistics from the UK Biobank Pharma Proteomics Project (UKB-PPP; Sun 2023 Nature) for a specific (protein, ancestry) measurement. Use when an agent needs per-variant beta / SE / p-value around a coloc-lead variant for downstream colocalisation, Mend...
Estimate divergence times under molecular-clock models with BEAST2, MCMCTree/PAML, TreePL, and LSD2, framing a date as a product of the calibration prior and the clock model far more than of the sequence data. Covers why branch length = rate x time is nonidentifiable so only calibrations convert ...
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