---
name: query-interpro
description: Query InterPro for protein domains and families. Use when user asks about protein domains, functional sites, protein families, domain architecture, or motifs. Triggers on "interpro", "protein domain", "domain architecture", "protein family", "functional site", "motif".
---

# InterPro Protein Domain Database

Query the InterPro REST API for protein domains, families, and functional sites.

## When to Use

- User asks about domains in a protein
- User wants to know what family a protein belongs to
- User asks about functional sites or motifs
- User wants domain architecture visualization

## How to Execute

```python
import requests
import json

BASE_URL = "https://www.ebi.ac.uk/interpro/api"

# 1. Get protein annotation (domains/families for a UniProt ID)
def get_protein_domains(uniprot_id):
    url = f"{BASE_URL}/protein/uniprot/{uniprot_id}"
    r = requests.get(url, headers={"Accept": "application/json"})
    r.raise_for_status()
    return r.json()

# 2. Get InterPro entry details
def get_interpro_entry(interpro_id):
    url = f"{BASE_URL}/entry/interpro/{interpro_id}"
    r = requests.get(url, headers={"Accept": "application/json"})
    r.raise_for_status()
    return r.json()

# 3. Search InterPro by text
def search_interpro(query, max_results=10):
    url = f"{BASE_URL}/entry/interpro"
    params = {"search": query, "page_size": max_results}
    r = requests.get(url, params=params, headers={"Accept": "application/json"})
    r.raise_for_status()
    return r.json()

# 4. Get domain matches for a protein
def get_domain_matches(uniprot_id):
    url = f"{BASE_URL}/protein/uniprot/{uniprot_id}/entry/interpro"
    r = requests.get(url, headers={"Accept": "application/json"})
    r.raise_for_status()
    return r.json()

# Example: TP53 domains
domains = get_domain_matches("P04637")
for result in domains.get("results", []):
    meta = result.get("metadata", {})
    name = meta.get("name", "N/A")
    ipr_type = meta.get("type", "N/A")
    accession = meta.get("accession", "N/A")
    proteins = result.get("proteins", [])
    if proteins:
        locations = proteins[0].get("entry_protein_locations", [])
        for loc in locations:
            for frag in loc.get("fragments", []):
                start = frag.get("start", "?")
                end = frag.get("end", "?")
                print(f"{accession} ({ipr_type}): {name} [{start}-{end}]")
```

## Entry Types

- `domain` — Structural/functional domain
- `family` — Protein family
- `homologous_superfamily` — Distant homologs
- `repeat` — Repeated motif
- `site` — Active/binding site

## Follow-up Suggestions

- "Want me to compare domains across species?"
- "Should I map these domains onto the 3D structure?"
- "Want me to find other proteins with the same domain?"


---
Source attribution: Runchuan-BU
Original project: https://github.com/Runchuan-BU/BioClaw
License: MIT
License information: https://opensource.org/license/mit
Original upstream instructions; downloaded from Dave AI.

## Upstream license notice

MIT License

Copyright (c) 2026 Gabriel Moreira

Permission is hereby granted, free of charge, to any person obtaining a copy
of this software and associated documentation files (the "Software"), to deal
in the Software without restriction, including without limitation the rights
to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
copies of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all
copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
SOFTWARE.



# Dave AI resource metadata

Creator / publisher: Runchuan-BU
Original project: https://github.com/Runchuan-BU/BioClaw
Attribution basis: Upstream repository explicitly recorded in package mirror path

Fields of work: Data & Analytics, Education & Research
Roles: Business Intelligence Analyst, Data Scientist, Researcher
Specialties: API, Cross Platform
Tools: Interpro Api
Country applicability: Country not specified
Classification basis: Source catalog labels
Instruction SHA-256: dcd160f831299d11f96dea658c88e5bc9ad7e9b749813352fc9e6a1925cc78d4