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Yachtkauf: Privater Kaeufer; Haendler; Flaggenregistrierung und Zollstatus bestellt Schiffshypothek als Sicherheit für Finanzierung eines Segel- oder Motorjacht. BGB §§ 433-479 Kaufrecht; SchRG §§ 8-74 wenn eingetragen; WRC 2007 ab 14 m. Notarielle Bestellungsurkunde, Rangstelle, Sicherungsabrede...
The apartment-hunt CLI that actually works in 2026 — Surf-cleared bot protection plus a local SQLite store the website itself doesn't have. Trigger phrases: `find apartments in <city>`, `watch apartment listings for <area>`, `rank rentals by price per square foot`, `compare these apartments`, `us...
Stingray-backed Redfin CLI with the workflows the website can't do — saved-search diff, sold-price trends, $/sqft ranking, and offline SQL. Trigger phrases: `find homes for sale in <city>`, `watch redfin listings for <area>`, `rank houses by price per square foot`, `pull sold comps for <address>`...
Drafts a mutual early lease termination agreement for U.S. commercial and residential properties. Covers party identification, termination mechanics, property surrender, financial settlement (prorated rent, security deposit accounting), mutual release with carve-outs, and execution formalities. U...
Transform single property/neighborhood images into photorealistic 3D Gaussian Splats using Apple's ml-sharp, enabling virtual walkthroughs from a single photograph. Bridge to PropertyPriceOracle for valuation analytics.
Grundbuchauszug analysieren: Eigentuemer, Belastungen, Grundschulden, Dienstbarkeiten. Normen: §§ 873 ff. 1105 ff. 1191 ff. BGB, GBO. Prüfraster: Abteilung I bis III, Widersprueche, Rangverhältnisse, Löschungsansprüche. Output: Grundbuchanalyse-Bericht mit Handlungsempfehlung. Abgrenzung: nicht K...
Prüfraster für die Beschlussanfechtung in der Wohnungseigentuemergemeinschaft nach §§ 44 ff. WEG-Reform 2020. Beschlussklage Anfechtungsklage Nichtigkeitsklage Feststellungsklage. Prüfung formelle Maengel (Ladung Tagesordnung Beschlussfähigkeit Mehrheit Stimmrechtsausschluesse) und materielle Mae...
LoopNet shows you today — this CLI remembers, building the price-cut, days-on-market, and supply trends LoopNet... Trigger phrases: `search loopnet for commercial real estate`, `find industrial properties for sale in`, `track price cuts on loopnet`, `what is the cap rate distribution in`, `screen...
SKILL DE RISCO \u2014 AUDITOR DE RISCO EM LEIL\u00d5ES workflow skill. Use this skill when the user needs Analise de risco em leiloes de imoveis. Score 36 pontos, riscos juridicos/financeiros/operacionais, stress test 4 cenarios e ROI ponderado por risco and the operator should preserve the upstr...
Explains ML predictions on omics data with SHAP, LIME, and permutation importance, handling the correlated-feature trap, the conditional-vs-interventional Shapley choice, and the attribution-is-not-causation boundary. Use when interpreting an omics classifier, debugging shortcut/batch learning, o...
Assigns taxonomy to amplicon ASVs/OTUs (16S, ITS, 18S) with a classifier conditioned on a reference database and primer region - DADA2 assignTaxonomy + addSpecies (RDP naive Bayes), DECIPHER IDTAXA, and QIIME2 q2-feature-classifier (classify-sklearn naive Bayes, classify-consensus-vsearch alignme...
End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/s...
Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for...
Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles res...
Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability...
Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outco...
Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sp...
Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, ...
Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR ...
Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth ...
Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted F...
Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample dist...
Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical...
Performs differential expression on bulk RNA-seq count data with edgeR's negative-binomial GLM and quasi-likelihood F-test framework. Covers DGEList construction, filterByExpr, TMM/TMMwsp normalization, robust dispersion estimation, glmQLFit/glmQLFTest, TREAT for magnitude-bounded hypotheses, con...
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